Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations
نویسندگان
چکیده
منابع مشابه
Lung clearance index in cystic fibrosis subjects treated for pulmonary exacerbations.
Pulmonary exacerbations are important clinical events for cystic fibrosis (CF) patients. Studies assessing the ability of the lung clearance index (LCI) to detect treatment response for pulmonary exacerbations have yielded heterogeneous results. Here, we conduct a retrospective analysis of pooled LCI data to assess treatment with intravenous antibiotics for pulmonary exacerbations and to unders...
متن کاملLung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis.
RATIONALE The lung clearance index (LCI) is a promising endpoint for use in cystic fibrosis (CF) clinical trials, but correlations with validated clinical endpoints have not yet been established. OBJECTIVE This study aimed to demonstrate that, in young patients with CF, baseline LCI predicts subsequent pulmonary exacerbation (PE) and correlates with the respiratory domain of the CF Questionna...
متن کاملLung clearance index in adults with non-cystic fibrosis bronchiectasis
BACKGROUND Lung clearance index (LCI) is a measure of abnormal ventilation distribution derived from the multiple breath inert gas washout (MBW) technique. We aimed to determine the clinical utility of LCI in non-CF bronchiectasis, and to assess two novel MBW parameters that distinguish between increases in LCI due to specific ventilation inequality (LCIvent) and increased respiratory dead spac...
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Pulmonary exacerbations have very important consequences in cystic fibrosis (CF), both in terms of current morbidity as well as implications for long term morbidity and mortality. Even though there is no universally agreed definition of pulmonary exacerbation, prompt and aggressive treatment with a multidisciplinary approach is recommended. Maintenance treatments reduce the risk of exacerbation...
متن کاملPulmonary exacerbations in cystic fibrosis and bronchiectasis.
unique characteristics. Taking these characteristics into account should enable a more accurate assessment of disease severity. Numerous examples exist of disease-specific scores that outperform generic scores, 14 including the PSI in the context of patients hospitalised with CAP. The study by Barlow et al extends this view to CURB65 in relation to SEWS and SIRS. However, the patient cohort in ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2015
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00211914